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Molecular Switch Linking Infectious Disease And Depression Identified

March 31, 2009

The researchers suspect that the metabolites produced when IDO degrades tryptophan are in some way promoting depression.

via Molecular Switch Linking Infectious Disease And Depression Identified.

Hmmm….so does that mean NSAIDS and antibiotics can treat depression?

  1. April 1, 2009 1:00 pm

    You raise a good question. It’s been well shown that inducing inflammation can lead to depression, but I’m not sure about using anti-inflammatory agents to treat clinical depression in patients who don’t have an inflammation problem from another drug or disease. I’m sure someone’s studying that as we speak.

    I had a class earlier in the year that spent a lot of time covering how the neuroendocrine stress response can lead to abnormal inflammatory activation as well as depression. (Chronic stress makes the body think it’s “sick” and activates cytokines as the immune system tries to fight the “sickness”.) The same talk covered depression induced in patients with inflammation from interferon treatment. That lecture was by Dr. Charles Raison, whose website has more information about his research on stress, inflammation, and depression, if you’re interested:

  2. April 1, 2009 1:18 pm

    Speaking of studying that right now:

    I wonder if it will work.

  3. April 10, 2009 2:28 pm

    Отличный блог, интересное и полезное содержание!

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